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Tuesday, August 30, 2011

What Can Affect the Success of IVF (In Vitro Fertilization)

By Phylis Dean

Many couples who cannot have children in the normal course of things use IVF. However there are factors that affect the chances of a successful outcome. Here are some of them. Remember to consult your physician for individual guidance.

IVF, standing for in vitro (glass) fertilization, is the term given for adding the man's sperm to the woman's egg in a laboratory setting, rather than through a natural process. Often couples who cannot conceive choose this path when they still wish to have children, which may be due to quality or quantity of sperm, or tube blocking or cervical issues in the woman. IVF success rates can depend on many factors.

The most common point of failure of IVF for a woman is her age. Effectiveness of treatment generally decreases as age increases, however it is difficult to get exact statistics on the matter. For women under 35, IVF is approximately 33% successful, and for women over the age of 44 it is typically under 5%. These percentages seem to be on the rise as technology develops year by year.

The physician administering the IVF treatment can also be a factor, as clinical pregnancy rates are able to vary between doctors in the same center, from 8% up to 40%. This may say more about different physicians appealing to different age bands of patients, but it is also possible that it is a reflection of their skill and ability. Smaller centers tend to be slightly less successful than large ones.

Around 12% of IVF cycles are cancelled before the egg is collected, and the most common cause for this is poor, or no, egg production at 83%. The patient may also have personal reasons to discontinue the treatment, such as deciding the treatment is not for them. The older the patient is, the higher chance the cycles have of being cancelled, suggesting a correlation between age and egg production.

Transfer numbers can affect the chance of having a live baby, as more transfers increases both the likelihood as well as the chance of multiple pregnancies. One transfer has a low rate of both, whereas three transfers is much higher. In the UK women under 40 are restricted to a maximum of two transfers, however some evidence suggests two is just as effective as three, and less likely to induce multiple pregnancies. Transfer is the term used for replacing an embryo.

It is likely that the couple has a problem with fertility when they seek IVF, and in some cases both the man and woman have issues. Donor sperm and eggs are available and can be more effective with a higher success rate than those using their own sperm and eggs. For donor eggs there is around a 40% overall delivery rate per transfer, against 30% non-donor.

Length of infertility for a couple can affect success rates, and those who have been infertile longer have less chance of a live birth baby at around 11%. Those who have only just recently became so have around a 20% chance. Cause of the infertility can factor into this too, as tubular problems and endometriosis affect the outcome more than male fertility seems to.

Previous pregnancies and pregnancies through IVF can help to boost the success rate, but lifestyle can also affect things as overweight women are less likely to become pregnant, or take longer to. Smoking also appears to reduce the chance of pregnancy, and race seems to have influence on IVF success rates based on distribution of fat, or which medical conditions they are vulnerable to.




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